AZ-GHS-22 |
| Catalog No.GC49321 |
L'AZ-GHS-22 est un puissant agoniste inverse GHS-R1a non pénétrant dans le SNC (IC50 = 0,77 nM) .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1143020-91-0
Sample solution is provided at 25 µL, 10mM.
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AZ-GHS-22 is an inverse agonist of the growth hormone secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.1 It binds to GHS-R1a with an IC50 value of 0.77 nM. AZ-GHS-22 decreases food intake in mice by 54% in the first two hours after administration of a 100 mg/kg dose.
1.McCoull, W., Barton, P., Brown, A.J.H., et al.Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonistsJ. Med. Chem.57(14)6128-6140(2014)
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