Abafungin (Synonyms: BAY-W 6341) |
| Catalog No.GC49766 |
L'abafungine, un agent antifongique, inhibe la transméthylation en position C-24 de la chaÎne latérale du stérol, catalysée par l'enzyme stérol-C-24-méthyltransférase.
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Cas No.: 129639-79-8
Sample solution is provided at 25 µL, 10mM.
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Abafungin is an antifungal agent.1 It is active against a variety of dermatophytes, yeast, molds, and other fungi (MICs = ≤0.06-2, 0.5-16, ≤0.06-1, and 0.25-8 µg/ml, respectively). Abafungin inhibits ergosterol biosynthesis, as well as acts directly on the fungal cell membrane to induce cell death.
1.Borelli, C., Schaller, M., Niewerth, M., et al.Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungiChemotherapy54(4)245-259(2022)
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