1-Carboxycyclohexaneacetic Acid (Synonyms: Gabapentin Impurity E, Gabapentin Related Compound E, NSC 90823) |
| Catalog No.GC49861 |
A potential impurity in commercial preparations of gabapentin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 67950-95-2
Sample solution is provided at 25 µL, 10mM.
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1-Carboxycyclohexaneacetic acid is a potential impurity in commercial preparations of the antiepileptic gabapentin.1 It has also been used as a precursor in the synthesis of antagonists of the serotonin (5-HT) receptor subtype 5-HT2A.2
1.Ragham, P.K., and Chandrasekhar, K.B.Development and validation of a stability-indicating RP-HPL C-CAD method for gabapentin and its related impurities in presence of degradation productsJ. Pharm. Biomed. Anal.125122-129(2016) 2.Obniska, J., Pawlowski, M., Kolaczkowski, M., et al.Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dionePol. J. Pharmacol.55(4)553-557(2003)
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