T2AA (hydrochloride) (Synonyms: T2-amino Alcohol) |
| Catalog No.GC44983 |
T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA). It inhibits protein-protein interactions between PCNA and a PIP-box-containing peptide (IC50 = 1 μM) and full-length p21 as well as reduces cellular colocalization of PCNA and DNA polymerase δ. T2AA inhibits DNA replication and cell growth in U2OS and HeLa cells in a concentration-dependent manner and induces cell cycle arrest at the S phase when used at a concentration of 20 μM. It also increases DNA double strand break formation induced by cisplatin in a neutral comet assay and cisplatin-induced inhibition of clonogenic survival in HeLa and U2OS cells.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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