CD73-IN-4 |
| Catalog No.GC62452 |
CD73-IN-4 est un inhibiteur puissant et sélectif de l'acide méthylènephosphonique CD73, avec une IC50 de 2,6 nM pour le CD73 humain.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2216764-29-1
Sample solution is provided at 25 µL, 10mM.
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CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology[1].
CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8[1].
[1]. Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5.
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