Chk1-IN-5 |
| Catalog No.GC60698 |
Chk1-IN-5 est un puissant inhibiteur de la kinase de point de contrÔle 1 (Chk1). Chk1-IN-5 inhibe la phosphorylation de Chk1 et inhibe la croissance tumorale dans le modèle de xénogreffe du cancer du cÔlon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2120398-39-0
Sample solution is provided at 25 µL, 10mM.
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Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model[1].
Chk1-IN-5 (compound 3; 0.4, 1.2, 3.7, 11.1, 33.3, 100 nM) inhibits Chk1 phosphorylation in the HT-29 colon cells[1].
Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells[1].Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr•kg; Vss=6.4 L/kg; AUC=4531 ng/ml•h)[1]. Animal Model: Baib/c nude mice with HT-29 colon cancer cells[1]
[1]. Xiong Cai, et al. 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (chk1) inhibitors, and their preparations and applications. WO2017132928A1.
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