D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Synonyms: Ins(2,4,5)P3 (sodium salt), 2,4,5IP3 (sodium salt)) |
| Catalog No.GC43533 |
The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.
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