Dapsone (Synonyms: 4,4'-Diaminodiphenyl sulfone, NSC 6091) |
| Catalog No.GC16306 |
La dapsone (4,4′-diaminodiphénylsulfone) est un antibiotique sulfamide actif par voie orale et pénétrant dans le sang et le cerveau avec des activités bactériostatiques, antimycobactériennes et antiprotozoaires.
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Cas No.: 80-08-0
Sample solution is provided at 25 µL, 10mM.
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Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2].
References:
[1]. Diaz-Ruiz, A., et al., Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res, 2008. 86(15): p. 3410-9.
[2]. Begon, E., O. Chosidow, and P. Wolkenstein, [Disulone]. Ann Dermatol Venereol, 2004. 131(12): p. 1062-73.
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