Desglymidodrine (Synonyms: ST 1059) |
| Catalog No.GC52051 |
La desglymidodrine (ST 1059), le métabolite actif de la midodrine, est un agoniste sélectif des récepteurs α1-adrénergiques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3600-87-1
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Desglymidodrine is the active metabolite of the prodrug midodrine .1 It is formed from midodrine by enzymatic hydrolysis.2 Desglymidodrine is an agonist of α1-adrenergic receptors (α1-ARs).1 It binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.
1.Altenbach, R.J., Khilevich, A., Kolasa, T., et al.Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing α1A-adrenoceptor agonistJ. Med. Chem.47(12)3220-3235(2004) 2.McClellan, K.J., Wiseman, L.R., and Wilde, M.I.Midodrine. A review of its therapeutic use in the management of orthostatic hypotensionDrugs Aging12(1)76-86(1998)
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *