DMH2 (Synonyms: VU364849) |
Catalog No.GC50210 |
Le DMH2 est un puissant antagoniste des récepteurs BMP. DMH2 régule négativement l'expression des protéines Id1 et Id3, et inhibe la prolifération et induit la mort cellulaire des lignées cellulaires du cancer du poumon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1206711-14-9
Sample solution is provided at 25 µL, 10mM.
Type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.
Tsugawa et al (2014) Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 351 549 PMID:25271257
Average Rating: 5
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