Echitamine chloride |
| Catalog No.GC63871 |
Le chlorure d'échitamine est le principal alcaloÏde indole monoterpène présent en Alstonie avec une puissante activité anti-tumorale. Le chlorure d'échitamine induit la fragmentation de l'ADN et l'apoptose des cellules. Le chlorure d'échitamine inhibe la lipase pancréatique avec une CI50 de 10,92 μM.
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Cas No.: 6878-36-0
Sample solution is provided at 25 µL, 10mM.
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Echitamine chloride is the major monoterpene indole alkaloid present in Alstonia with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 µM[1][2].
[1]. Ganesh Chandra Jagetia, et al. Evaluation of the Cytotoxic Effect of the Monoterpene Indole Alkaloid Echitamine In-Vitro and in Tumour-Bearing Mice. J Pharm Pharmacol. 2005 Sep;57(9):1213-9.
[2]. Ginson George, et al. Development and Validation of a New HPTLC-HRMS Method for the Quantification of a Potent Pancreatic Lipase Inhibitory Lead Echitamine From Alstonia scholaris. Nat Prod Res. 2019 Dec 24;1-5.
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