Enobosarm-d4 (Synonyms: (S)-Enobosarm-d4) |
Catalog No.GC49648
One-Click Copy Product Info
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An internal standard for the quantification of enobosarm
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1202044-20-9
Sample solution is provided at 25 µL, 10mM.
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Enobosarm-d4 is intended for use as an internal standard for the quantification of enobosarm by GC- or LC-MS. Enobosarm is a non-steroidal selective androgen receptor modulator (SARM; Ki = 0.0038 µM in a radioligand binding assay).1 It is a partial agonist of the androgen receptor (IC50 = 0.0364 µM in a transactivation assay) and inhibits the proliferation of 22Rv1, DU145, LNCaP, and VCaP prostate cancer cells (IC50s = 24.77, 44.55, 20.9, and 24.47 µM, respectively).2 Enobosarm (0.001 and 0.01 µM) inhibits lipogenesis in isolated rat adipocytes.3 It increases the weights of the prostate gland and seminal vesicles, markers of androgenic activity, and the levator ani muscle, a marker of anabolic activity, in castrated rats (ED50s = 0.12, 0.39, and 0.03 mg/day, respectively).1
1.Kim, J., Wu, D., Hwang, D.J., et al.The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulatorsJ. Pharmacol. Exp. Ther.315(1)230-239(2005) 2.Bassetto, M., Ferla, S., Pertusati, F., et al.Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancerEur. J. Med. Chem.118230-243(2016) 3.Leciejewska, N., Pruszynska-Oszmalek, E., Bien, J., et al.Effect of ostarine (enobosarm/GTX024), a selective androgen receptor modulator, on adipocyte metabolism in Wistar ratsJ. Physiol. Pharmacol.70(4)525-533(2019)
| Cas No. | 1202044-20-9 | SDF | |
| Synonymes | (S)-Enobosarm-d4 | ||
| Canonical SMILES | FC(F)(C1=C(C=CC(NC([C@@](C)(O)COC2=C([2H])C([2H])=C(C([2H])=C2[2H])C#N)=O)=C1)C#N)F | ||
| Formula | C19H10D4F3N3O3 | M.Wt | 393.4 |
| Solubility | DMF: soluble,DMSO: soluble,Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5419 mL | 12.7097 mL | 25.4194 mL |
| 5 mM | 508.4 μL | 2.5419 mL | 5.0839 mL |
| 10 mM | 254.2 μL | 1.271 mL | 2.5419 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)