Enzalutamide carboxylic acid |
| Catalog No.GC60808 |
L'acide carboxylique d'enzalutamide (acide carboxylique MDV3100) est un métabolite inactif de l'enzalutamide (MDV3100). L'enzalutamide est un antagoniste des récepteurs aux androgènes (AR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1242137-15-0
Sample solution is provided at 25 µL, 10mM.
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Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1].
Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive[1].
[1]. van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.
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