G140 |
| Catalog No.GC62664 |
G140 est un inhibiteur puissant et sélectif de la GMP-AMP synthase cyclique (cGAS), avec des IC50 de 14,0nM et 442nM pour h-cGAS et m-cGAS, respectivement.
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Cas No.: 2369751-07-3
Sample solution is provided at 25 µL, 10mM.
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G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].
G140 (0.1-100 µM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC50s of 1.70 and 0.86 µM in human THP1 and primary macrophages, respectively[1].G140 (0.1-100 µM; 24 h) inhibits cells viability with a LD50 of >100 µM in THP1 cells[1].
[1]. Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261.
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