4-Methyldaphnetin |
| Catalog No.GC35138 |
La 4-méthyldaphnétine est un précurseur dans la synthèse des dérivés de la 4-méthyl coumarine. La 4-méthyldaphnétine a des effets anti-prolifératifs et inducteurs d'apoptose puissants et sélectifs sur plusieurs lignées cellulaires cancéreuses. La 4-méthyldaphnétine possède une propriété de piégeage des radicaux et inhibe fortement la peroxydation des lipides membranaires.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2107-77-9
Sample solution is provided at 25 µL, 10mM.
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4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3].
[1]. VÁzquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21. [2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4.
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