Bioymifi (Synonyms: DR5 Activator) |
| Catalog No.GC35523 |
Bioymifi (DR5 Activator), un puissant activateur DR5 du récepteur TRAIL, se lie au domaine extracellulaire (ECD) de DR5 avec un Kd de 1,2 μM. Bioymifi peut agir comme un agent unique pour induire le regroupement et l'agrégation de DR5, conduisant À l'apoptose.
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Cas No.: 1420071-30-2
Sample solution is provided at 25 µL, 10mM.
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Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.IC50 value:Target: In comparison with A2C2, bioymifi was able to promote cell death without the need for the Smac mimetic in T98G cells. Notably, at a 10-μM concentration, bioymifi induced processing of caspase-3 into smaller fragments. Z-VAD inhibited these caspase-mediated cleavages. caspase-3 was rapidly activated as early as 2 h after bioymifi treatment of T98G cells. The caspase-3 activity was markedly increased after 8 h of treatment. Bioymifi induces caspase-8-dependent apoptosis.
[1]. Wang G, et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb;9(2):84-9.
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