CAY10471 Racemate |
| Catalog No.GC35620 |
CAY10471 Racemate (TM30089 Racemate) est un antagoniste puissant et hautement sélectif du récepteur CRTH2 de la prostaglandine D2, avec un Ki de 0,6 nM pour hCRTH2, sélectif par rapport au récepteur humain thromboxane A2 TP (Ki, > 10 000 nM) ou au récepteur PGD2 DP (Ki, 1 200 nM ).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 844639-57-2
Sample solution is provided at 25 µL, 10mM.
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CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1]. Ki: 0.6 nM (CRTH2), 1200 nM (DP)[1]
CAY10471 Racemate (Compound 13) inhibits PGD2-induced inositol phosphate or cAMP formation, suppresses β-arrestin translocation with IC50s of 12 and 3 nM, respectively[1].
[1]. Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900.
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