Eniluracil (Synonyms: 776C85, 5-Ethynyluracil, NSC 687296) |
| Catalog No.GC35992 |
L'éniluracil (5-éthynyluracile) est un inhibiteur de la dihydropyrimidine déshydrogénase (DPD) actif par voie orale. L'éniluracil inhibe de manière irréversible la DPD, augmente la biodisponibilité orale du 5-fluorouracile À 100 % et facilite l'absorption uniforme et la toxicité du 5-fluorouracile. L'éniluracil peut être utilisé dans la recherche sur le cancer en association avec des fluoropyrimidines (y compris le 5-fluorouracile).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 59989-18-3
Sample solution is provided at 25 µL, 10mM.
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Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity[1]. Dihydropyrimidine dehydrogenase[1]
[1]. Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.
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