Tafamidis meglumine |
| Catalog No.GC37720 |
Tafamidis méglumine (Fx-1006A) est un stabilisant puissant et sélectif de la transthyrétine (TTR), présente une puissance et une efficacité comparables aux homotétramères mutants V30M-TTR, V122I-TTR et WT-TTR de type sauvage, avec des CE50 de 2,7 À 3,2 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 951395-08-7
Sample solution is provided at 25 µL, 10mM.
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Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1]. EC50: 2.7-3.2 μM (TTR)[1]
Tafamidis binds selectively and with negative cooperativity (Kds ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR[1].Tafamidis (0-7.2 μM) dose-dependently inhibits WT-TTR amyloidogenesis after treatment for 72 hours at a pH of 4.4-4.5[1].
[1]. Bulawa CE, et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34.
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