Rac-VU 6008667 |
| Catalog No.GC38111 |
Rac-VU 6008667 est un modulateur allostérique négatif sélectif du sous-type 5 du récepteur muscarinique de l'acétylcholine (M5 NAM) (IC50 \u003d 1,8 μM, pIC50 \u003d 5,75), a une pénétration élevée dans le SNC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2092917-63-8
Sample solution is provided at 25 µL, 10mM.
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Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. Rac-VU 6008667 has high CNS penetration[1]. M5 NAM: muscarinic acetylcholine receptor subtype 5.
[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.
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