GFB-8438 |
| Catalog No.GC39488 |
Le GFB-8438 est un inhibiteur de TRPC5 puissant et sélectif de sous-type, avec des IC50 de 0,18 et 0,29 μM de hTRPC5 et hTRPC4, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2304549-73-1
Sample solution is provided at 25 µL, 10mM.
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GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model[1].
[1]. Yu M, et al.Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.ACS Med Chem Lett. 2019 Oct 22;10(11):1579-1585.
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