Ghrelin (rat) |
| Catalog No.GC11583 |
Ghrelin (rat), a growth hormone-releasing peptide first discovered in rat stomach in 1999, is a ligand for the growth hormone secretagogue receptor.
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Cas No.: 258338-12-4
Sample solution is provided at 25 µL, 10mM.
Ghrelin (rat), a growth hormone-releasing peptide first discovered in rat stomach in 1999, is a ligand for the growth hormone secretagogue receptor[1，2].
Retroperitoneal (RP) adipocytes were cultured in the absence or presence of either Ghrelin (rat) or desacyl Ghrelin (rat) and in combination with either inhibitors of protein synthesis, insulin, dexamethasone (DXM), or GHSR1a antagonist. The results indicate that both Ghrelin (rat) forms possess a direct leptin-releasing activity (LRA) on RP adipocytes and significantly enhanced adipocyte ob mRNA expression[4].
Ghrelin (rat) and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique. Ghrelin (rat) decreased, while GHRP-6 in fasted, but not fed, rats selectively increased islet blood flow fourfold[3]. The initial electrophysiological results displayed that ex vivo administration of Ghrelin (rat) increased NAc shell output in brain slices from drug- and training-naÏve rats. In rats with an acquired skilled reach performance, acute as well as repeated treatment with a Ghrelin (rat) receptor (GHSR-1 A) antagonist decreased the number of sucrose pellets consumed[5]. Ghrelin (rat) administration attenuated sepsis symptoms induced by CLP. Blood flow in the stomach greater curvature was significantly higher in the CLP induced sepsis group rats compared with the sham operation group, whereas there was no difference between the CLP group treated with Ghrelin (rat) and the sham rats. Ghrelin (rat) administration also reduced the secretion of pro inflammatory cytokines compared with the CLP induced sepsis group rats[6]. Ghrelin (rat) signaling increases the reward from social interaction in a manner that reflects the degree of divergence in body weight between the social pair[7].
References:
[1]. Tokudome T, Kangawa K. Physiological significance of ghrelin in the cardiovascular system. Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(8):459-467. doi: 10.2183/pjab.95.032. PMID: 31611501; PMCID: PMC6819151.
[2]. Kojima M, Hosoda H, et,al.in is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999 Dec 9;402(6762):656-60. doi: 10.1038/45230. PMID: 10604470.
[3]. Drott CJ, FranzÉn P, et,al. Ghrelin in rat pancreatic islets decreases islet blood flow. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E139-E146. doi: 10.1152/ajpendo.00004.2019. Epub 2019 May 7. PMID: 31063397.
[4]. Giovambattista A, Gaillard RC, et,al.Ghrelin gene-related peptides modulate rat white adiposity. Vitam Horm. 2008;77:171-205. doi: 10.1016/S0083-6729(06)77008-X. PMID: 17983857.
[5]. Vestlund J, Bergquist F, et,al. Ghrelin signalling within the rat nucleus accumbens and skilled reach foraging. Psychoneuroendocrinology. 2019 Aug;106:183-194. doi: 10.1016/j.psyneuen.2019.04.008. Epub 2019 Apr 8. PMID: 30999229.
[6]. Li B, Lin Q, et,al.Ghrelin regulates sepsis?induced rat acute gastric injury. Mol Med Rep. 2019 Jun;19(6):5424-5432. doi: 10.3892/mmr.2019.10208. Epub 2019 Apr 30. PMID: 31059095; PMCID: PMC6522907.
[7]. SchÉle E, Pfabigan DM, et,al. Ghrelin Induces Place Preference for Social Interaction in the Larger Peer of a Male Rat Pair. Neuroscience. 2020 Nov 1;447:148-154. doi: 10.1016/j.neuroscience.2020.01.027. Epub 2020 Feb 5. PMID: 32032669.
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