GLUT inhibitor-1 |
| Catalog No.GC64876 |
L'inhibiteur GLUT-1 est un inhibiteur puissant et actif par voie orale des transporteurs de glucose, ciblant À la fois GLUT1 et GLUT3, avec des IC50 de 242 nM et 179 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2421141-40-2
Sample solution is provided at 25 µL, 10mM.
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GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].
Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1]. Parameter Mouse Rat oral Cmax (ng/mL)25251675 oral AUC (ng/mL)58906813 CL (mL/min/kg)4037 Vdss (L/Kg)1.70 4.51 t1/2 (h)0.7852.59 F (%)45.449.4 B/Pb0.05b: Solubility is determined in PBS buffer solutions.
[1]. Liu KG, et al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020;63(10):5201-5211.
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