Ispronicline |
| Catalog No.GC63548 |
L'ispronicline (TC-1734), un agoniste partiel du récepteur de l'acétylcholine nicotinique α4β2 (nAChR) actif par voie orale et sélectif pour le cerveau, a montré des propriétés d'amélioration de la mémoire chez les rongeurs et un bon profil de tolérance.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 252870-53-4
Sample solution is provided at 25 µL, 10mM.
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Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2].
Ispronicline (10-20 mg/kg; s.c.) induces c-Fos expression in selective regions of the rat forebrain[1]. Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d)[2].
[1]. Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515(1):7-11.
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