LC3-mHTT-IN-AN1 |
| Catalog No.GC39395 |
LC3-mHTT-IN-AN1 (composé AN1) est un composé de liaison mHTT-LC3, qui interagit À la fois avec la protéine huntingtine mutante (mHTT) et LC3B mais pas avec wtHTT ou des protéines de contrÔle non pertinentes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 486443-73-6
Sample solution is provided at 25 µL, 10mM.
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LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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