Litronesib (LY-2523355) |
Catalog No.GC31803 |
Le litronesib (LY-2523355) (LY2523355) est un inhibiteur sélectif de la kinésine Eg5 spécifique de la mitose, avec une activité antitumorale.
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Cas No.: 910634-41-2
Sample solution is provided at 25 µL, 10mM.
Litronesib is a selective Eg5 inhibitor, with antitumor activity.
Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)[1].
Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].
[1]. Ye XS, et al. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol Cancer Ther. 2015 Nov;14(11):2463-72.
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