LQZ-7I |
| Catalog No.GC60229 |
LQZ-7I est un inhibiteur ciblant la survivine. LQZ-7I inhibe la dimérisation de la survivine. LQZ-7I inhibe efficacement par voie orale la croissance tumorale des xénogreffes et induit une perte de survivine dans les tumeurs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 195822-23-2
Sample solution is provided at 25 µL, 10mM.
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LQZ-7I is a surviving-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors[1].
LQZ-7I has improved cytotoxicity with IC50s of 3.1 µM against C4-2 cells and 4.8 µM against PC-3 cells compared with the parent compound LQZ-7[1]. LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin[1]. Western Blot Analysis[1] Cell Line: PC-3 or C4-2 cells
LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice[1]. Animal Model: 6-week old male NSG mice[1]
[1]. Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.
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