M2698 (Synonyms: MSC2363318A) |
| Catalog No.GC39715 |
M2698 (MSC2363318A) est un double inhibiteur sélectif de p70S6K et Akt actif par voie orale, compétitif pour l'ATP, avec des IC50 de 1 nM pour p70S6K, Akt1 et Akt3. Le M2698 peut traverser la barrière hémato-encéphalique et a une activité anticancéreuse.
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Cas No.: 1379545-95-5
Sample solution is provided at 25 µL, 10mM.
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M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity[1].
[1]. Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6(4):806-18.
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