N-Desethylamiodarone (hydrochloride) |
| Catalog No.GC44346 |
La N-déséthylamiodarone (chlorhydrate) (chlorhydrate de N-déséthylamiodarone) est un métabolite actif majeur de l'amiodarone.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 96027-74-6
Sample solution is provided at 25 µL, 10mM.
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Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 µM. In humans, cytochrome P450 3A is involved in the metabolism of amiodarone. N-Desethylamiodarone is the major, active metabolite of amiodarone. This compound has been used as an analytical reference standard for quantifying amiodarone in plasma samples.
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