N6-Cyclopentyladenosine (Synonyms: CPA, UK 80882) |
| Catalog No.GC14369 |
La N6-cyclopentyladénosine (CPA) est un agoniste sélectif des récepteurs de l'adénosine A1, avec des valeurs de Ki de 2,3nM, 790nM et 43nM pour les récepteurs humains A1, A2A et A3, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41552-82-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
N6-Cyclopentyladenosine is a selective agonist at adenosine 1 receptors (A1Rs) (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively, in transfected CHO cells).[1],[2] When microinjected into the rat brainstem, it increases blood pressure and heart rate.[3] It is effective for pain in normal and nerve-injured rats and shows anticonvulsant activity in a rat model of generalized seizures.[4],[5]
Reference:
[1]. Klotz, K.-N. Adenosine receptors and their ligands. Naunyn-Schmiedeberg's Arch. Pharmacol. 362(4), 382-391 (2000).
[2]. Klotz, K.-N., Hessling, J., Hegler, J., et al. Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 357, 1-9 (1998).
[3]. Barraco, R.A., el-Ridi, M.R., Ergene, E., et al. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26(1), 59-84 (1991).
[4]. Gong, Q.-J., Li, Y.-Y., Xin, W.-J., et al. Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. Brain Res. 1361, 23-30 (2010).
[5]. Jaishree, J., Kumaresan, S., Sudha, S., et al. Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline-induced recurrent generalized seizures in mice. Pol. J. Pharmacol. 55(4), 559-564 (2003).
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *