Naftopidil (hydrochloride) (Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride) |
| Catalog No.GC44311 |
Le naftopidil (chlorhydrate) (chlorhydrate de KT-611) est un antagoniste sélectif des récepteurs alpha1-adrénergiques, avec un Kis de 3,7 nM, 20 nM et 1,2 nM pour les sous-types humains clonés α1a-, α1b- et α1d-adrénergiques, respectivement. Le naftopidil (chlorhydrate) a des effets antiprolifératifs. Le naftopidil (chlorhydrate) peut être utilisé pour la recherche de l'hyperplasie de la prostate.
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Cas No.: 1164469-60-6
Sample solution is provided at 25 µL, 10mM.
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Naftopidil is an α1-adrenergic receptor antagonist that competitively inhibits α-adrenoceptor-mediated contractions induced by noradrenaline with pA2 values of 6.73-8.15 in various blood vessels from dog, rabbit, guinea pig, and rat. It binds to the cloned human α1-adrenergic receptors with Ki values of 3.7, 20, and 1.2 nM for α1A, α1B and α1D, respectively. Clinical formulations of naftopidil are used in the treatment of benign prostatic hyperplasia in Japan. Naftopidil also exhibits antiproliferative activity, inhibiting the growth of androgen-sensitive LNcaP cells and androgen-insensitive PC-3 cancer cell lines with IC50 values of 22.2 and 33.2 µM, respectively.
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