Necrostatin-5 (Synonyms: Nec-5) |
| Catalog No.GC41114 |
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis.
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Cas No.: 337349-54-9
Sample solution is provided at 25 µL, 10mM.
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Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.
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