Nociceptin (1-13)NH2 |
| Catalog No.GC12316 |
La nociceptine (1-13)NH2 est un puissant agoniste du récepteur ORL1 (récepteur de type récepteur opioÏde 1, OP4) avec une pEC50 de 7,9 pour le canal déférent de la souris et un Ki de 0,75 nM pour la liaison aux membranes du cerveau antérieur du rat.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 178064-02-3
Sample solution is provided at 25 µL, 10mM.
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Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].
References:
[1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.
[2]. Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.
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