O-Desmethyl Midostaurin (Synonyms: CGP62221; O-Desmethyl PKC412) |
| Catalog No.GC60274 |
La O-desméthyl midostaurine (CGP62221; O-desméthyl PKC412) est le métabolite actif de la midostaurine via le métabolisme des enzymes hépatiques du cytochrome P450. La O-Desméthyl Midostaurine peut être utilisée comme indicateur du métabolisme de la Midostaurine in vivo. La midostaurine est un inhibiteur de protéine kinase multi-cibleavecIC50allant de 22 À 500nM.
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Cas No.: 740816-86-8
Sample solution is provided at 25 µL, 10mM.
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O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.
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