PF-5190457 (Synonyms: PF-05190457) |
| Catalog No.GC31478 |
PF-5190457 (PF-05190457) est un agoniste inverse puissant et sélectif des récepteurs de la ghréline avec un pKi de 8,36.
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Cas No.: 1334782-79-4
Sample solution is provided at 25 µL, 10mM.
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PF-5190457 is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36.
PF-5190457 has a superior balance of ghrelin receptor pharmacology and off-target selectivity[1].
PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion in human whole and dispersed islets[1].
[1]. Bhattacharya SK, et al. Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate. ACS Med Chem Lett. 2014 Feb 24;5(5):474-9.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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