Platencin |
| Catalog No.GC40880 |
Platencin est un antibiotique Gram positif naturel À large spectre isolé de S.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869898-86-2
Sample solution is provided at 25 µL, 10mM.
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Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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