(Rac)-Tavapadon (Synonyms: (Rac)-PF-06649751; (Rac)-CVL-751) |
| Catalog No.GC60003 |
(Rac)-Tavapadon ((Rac)-PF-06649751) est un agoniste puissant et sélectif des récepteurs D1 de la dopamine non catéchol.
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Cas No.: 1643462-64-9
Sample solution is provided at 25 µL, 10mM.
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(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1].
(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751; compound 32) has EMAXs of 118% and 30% in the GS activation assay and the β-arrestin2 recruitment assay[1].
[1]. Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182.
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