NIC3 |
| Catalog No.GC36735 |
NIC3 est un inhibiteur sélectif de la protéine-1 associée au noyau accumbens (NAC1), se lie au Leu-90 conservé de NAC1, empêche son homodimérisation et conduit À la dégradation de NAC1 par le protéasome. Activité anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 494830-67-0
Sample solution is provided at 25 µL, 10mM.
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NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1]. NAC1[1]
[1]. Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664.
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