SHP836 |
| Catalog No.GC60337 |
SHP836 est un inhibiteur allostérique de SHP2, avec une IC50 de 12 μM pour la SHP2 pleine longueur.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1957276-35-5
Sample solution is provided at 25 µL, 10mM.
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SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2[1].
SHP836 stabilizes the active conformation of SHP2, in which the catalytic site is blocked and no longer accessible to substrate[1].
[1]. Liu WS, et al. Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation. J Comput Aided Mol Des. 2019 Aug;33(8):759-774. [2]. Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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