SMI-481 |
| Catalog No.GC44905 |
Le SMI-481 est un inhibiteur sélectif de la protéine de transfert de phosphatidylinositol de levure (PITP) Sec14.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 432020-20-7
Sample solution is provided at 25 µL, 10mM.
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Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively). Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14. Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs.
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