Accueil>>Peptides>>Tat-Gap 19 (trifluoroacetate salt)

Tat-Gap 19 (trifluoroacetate salt)

Catalog No.GC91472 Copy One-Click Copy Product Info

Tat-Gap 19 est un inhibiteur peptidique des hémicanaux de connexine43 (Cx43).

Products are for research use only. Not for human use. We do not sell to patients.

Tat-Gap 19 (trifluoroacetate salt) Chemical Structure

Taille Prix Stock Qté
500μg
161,00 $US
En stock
1mg
307,00 $US
En stock
5mg
805,00 $US
En stock

Tel:(909) 407-4943 Email: sales@glpbio.com


Avis des clients

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of Tat-Gap 19 (trifluoroacetate salt)

Tat-Gap 19 is a peptide inhibitor of connexin43 (Cx43) hemichannels.1 It is composed of the HIV-1 Tat protein transduction domain linked to a nine-amino acid peptide corresponding to residues 128-136 of Cx43. Tat-Gap 19 (10 µM) inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary rat hepatocytes.2 It reduces infarct volume in a mouse model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 25 mg/kg.1 Intraperitoneal infusion of Tat-Gap 19 (1 mg/kg per day) reduces fibrotic lesion area and the area of hepatic stellate cells, precursors of myofibroblasts, expressing α-smooth muscle actin (α-SMA) in a mouse model of thioacetamide-induced liver injury.2 It increases superoxide dismutase (SOD) activity in hepatic cells isolated from the same mice.

Chemical Properties of Tat-Gap 19 (trifluoroacetate salt)

Cas No. SDF
Formula C119H212N46O26 ? XCF3COOH M.Wt 2703.3
Solubility Water: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Tat-Gap 19 (trifluoroacetate salt)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 369.9 μL 1.8496 mL 3.6992 mL
5 mM 74 μL 369.9 μL 739.8 μL
10 mM 37 μL 185 μL 369.9 μL
  • Molarity Calculator

  • Dilution Calculator

  • Molecular Weight Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution) of Tat-Gap 19 (trifluoroacetate salt)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

Avis

Review for Tat-Gap 19 (trifluoroacetate salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%