TCL053 |
| Catalog No.GC52055 |
TCL053 est un support lipidique ionisable et utilisé pour introduire des composants actifs, en particulier des acides nucléiques, dans des cellules avec une excellente efficacité.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361162-70-9
Sample solution is provided at 25 µL, 10mM.
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TCL053 is an ionizable amino lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) and has a pKa value of 6.8. LNPs containing TCL053 and encapsulating mRNA encoding the Cas9 nuclease, in combination with LNPs containing TCL053 and encapsulating single-guide RNA (sgRNA) targeting the Rosa26 locus, have been used to induce CRISPR-mediated gene editing in the mouse gastrocnemius muscle.
1.Kenjo, E., Hozumi, H., Makita, Y., et al.Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in miceNat. Commun.12(1)7101(2021)
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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