TM-1 |
Catalog No.GC65502 |
TM-1 est un puissant inhibiteur de la pyruvate déshydrogénase kinase (PDHK1). TM-1 inhibe PDHK1 et PDHK2 avec des IC50 de 2,97 μM et 5,2 μM, respectivement. TM-1 bloque la phosphorylation du complexe pyruvate déshydrogénase (PDHC) et inhibe la prolifération cellulaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 921099-13-0
Sample solution is provided at 25 µL, 10mM.
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation[1].
TM-1 (0-10 μM) inhibits PDHK1 activity with the inhibition rate of 80.5% (dosage at 10 μM) and an IC50 value of 2.97 μM[1].TM-1 (0-2.1 μM; 12 h) shows anti-osteosarcoma activity and inhibits MG-63 cells with an EC50 value of 14.5 μM[1].TM-1 (3, 6, 12 μM; 24 h) decreases PDHC phosphorylation of both Ser293 and Ser232 sites in a dose-dependent manner[1].
[1]. Fang A, et al. Identification of pyruvate dehydrogenase kinase 1 inhibitors with anti-osteosarcoma activity. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5450-5453.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *