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UK 122 (trifluoroacetate salt)

Catalog No.GC91406 Copy One-Click Copy Product Info

Le UK 122 est un inhibiteur de l'activateur de plasminogène de type urokinase (uPA ; IC50 = 0,2 µM).

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UK 122 (trifluoroacetate salt) Chemical Structure

Cas No.: 1186653-73-5

Taille Prix Stock Qté
1mg
69,00 $US
En stock
5mg
202,00 $US
En stock

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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of UK 122 (trifluoroacetate salt)

UK 122 is an inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 0.2 µM).1 It is selective for uPA over tissue-type plasminogen activator (tPA), trypsin, plasmin, and thrombin (IC50s = >100 µM for all). UK 122 (100 µM) inhibits the migration and invasion of CFPAC-1 pancreatic cancer cells. It prevents glutamate-induced phase shifts in isolated suprachiasmatic nucleus slices from tPA-/- but not wild-type mice when used at a concentration of 0.2 µM.2 UK 122 (4 mg/kg) decreases disease severity and colorectal levels of RANTES in a mouse model of colitis induced by dextran sulfate (DSS; ).3

Chemical Properties of UK 122 (trifluoroacetate salt)

Cas No. 1186653-73-5 SDF
Formula C17H13N3O2 ? CF3COOH M.Wt 405.3
Solubility Acetonitrile: Soluble,Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of UK 122 (trifluoroacetate salt)

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1 mg 5 mg 10 mg
1 mM 2.4673 mL 12.3365 mL 24.6731 mL
5 mM 493.5 μL 2.4673 mL 4.9346 mL
10 mM 246.7 μL 1.2337 mL 2.4673 mL
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In vivo Formulation Calculator (Clear solution) of UK 122 (trifluoroacetate salt)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for UK 122 (trifluoroacetate salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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