GPCR/G protein

KBP-089 is a dual Amylin and Calcitonin Receptor agonist.

Gramine-d 2 is the deuterium labeled Gramine [1] . Gramine (Donaxine) is a natural alkaloid isolated from giant reed [2] , acts as an active adiponectin receptor (AdipoR) agonist, with IC 50 s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively [2] . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist [3] . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties [2] .

Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a K d of 7.2 nM.

Vedastotug is a human monoclonal antibody targeting TNFRSF4/OX40/CD134, with its corresponding isotype control being Human IgG1 kappa, Isotype Control [1] .

CTR/AMYR modulator-1 is a calcitonin receptor/amylin receptor modulator.

CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist.

Mazapertine is an orally active antipsychotic agent.

PG-901 is a full, selective MC5R agonist ( EC 50 = 0.072 nM for hMC5R).

PIPE-791 is an orally active, blood-brain barrier-permeable selective antagonist of LPAR1.

Betovumeline hydrochloride is the agonist for muscarinic receptor and can be used for researchs of neurological disorders [1] .

4-Piperidyl N-(2-biphenyl)carbamate (compound MA) is a competitive muscarinic acetylcholine receptor ( mAChR ) antagonist.

Direclidine (NBI-1117568, HTL-0016878) citrate is a selective orthosteric agonist targeting the muscarinic acetylcholine M4 receptor, exhibiting very low affinity for M1, M2, M3, and M5 receptors.

HTL-9936 is an orally active partial agonist of muscarinic M1 receptor.

PRAME peptide (425-433) acetate is a proteasome-degraded peptide derived from the cancer-testis antigen PRAME (Preferentially Expressed Antigen in Melanoma ).

Modimelanotide (ABT-719) acetate is an α-melanocyte-stimulating hormone analog.

XAT-14 is a Furanocoumarin derivative.

GS-5759 is both a β₂-adrenergic receptor agonist and a PDE4 inhibitor.

CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM.

VU0477573 is a brain-penetrant partial negative allosteric modulator of metabotropic glutamate receptor subtype 5 ( mGluR5 ).

VU6066098 is a blood-brain barrier penetrant, orally active inhibitor of metabotropic glutamate receptor subtype 2 ( mGlu2 ), with IC 50 values of 77 nM and 111 nM against human and rat targets, respectively.

MPPG TFA, phenylglycine analogue, is a potent and selective metabotropic glutamate receptor ( mGluR ) antagonist with a k D value of 9.2 μM.

VU6053371 (BI03738809) is a first-in-class (FIC), selective, orally active, and brain-penetrant metabotropic glutamate receptor subtype 3 ( mGlu3 ) positive allosteric modulator (PAM) with EC 50 s of 103 nM and 112 nM for human and rat mGlu3.

NNC0165-1273 acetate is a selective NPY Y2 receptor agonist with a K i of 2 nM and an EC 50 of 5.0 nM.

Fmoc-DL-Leu-OH acts as a partial agonist of the neurotensin NTS1 receptor ( NTS1R ) with an EC 50 of 215.50 μM.