Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(74)
- DNA Methyltransferase(43)
- HDAC(250)
- Histone Acetyltransferases(100)
- Histone Demethylases(120)
- Histone Methyltransferase(278)
- HIF(127)
- JAK(190)
- PARP(162)
- Pim(35)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(88)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(295)
- MicroRNA(33)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(16)
- METTL3(4)
- WDR5(8)
- TET Protein(2)
- HuR(2)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1948)
- GC80930DNMT1 Degrader-1CAS: 2962943-72-0Purity: >99.00%
DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC 50 of 202.87 nM and a Kd value of 122 nM.
- GC80934PROTAC BRD4 Degrader-49CAS: 3115940-40-1Purity: >98.00%
BRD4 degrader-8 is a BRD4 -targeting degrader.
- GC80936PROTAC BLIMP-1 degrader-1Purity: >98.00%
PROTAC BLIMP-1 degrader-1 is an orally active BLIMP-1 PROTAC degrader with an EC 50 of 13.1 nM.
- GC80937PROTAC KAT6 Degrader-1Purity: >98.00%
PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader.
- GC80946PROTAC JAK1/2 degrader-1Purity: >99.00%
PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.
- GC80947JAK1/2 ligand 1CAS: 1026028-96-5Purity: >99.50%
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.
- GC81024PROTAC RNF4 degrader-1Purity: >98.00%
PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system.
- GC81026PROTAC SKP2 Degrader-1CAS: 3120650-15-6Purity: >99.50%
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.
- GC81027PROTAC HIF-1α degrader-2CAS: 3095636-64-6Purity: >98.00%
PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.
- GC81312PARP1/c-Met-IN-3CAS: 3123529-62-1Purity: >98.00%
PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1.
- GC81400Adenosine-3',5'-bisphosphate ammonium solution (100 mM)Purity: >99.00%
Adenosine-3',5'-bisphosphate ammonium is a XRN1 inhibitor ( IC 50 = 36 nM).
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC80929 | PLX-4104 | 2851986-77-9 | >98.00% | |
PLX-4104 is an orally active BRD4 molecular glue degrader with a DC 50 of 2 nM. | ||||
| GC80930 | DNMT1 Degrader-1 | 2962943-72-0 | >99.00% | |
DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC 50 of 202.87 nM and a Kd value of 122 nM. | ||||
| GC80931 | dHTC3 | - | >98.00% | |
dHTC3 is a selective BRD4 molecular glue degrader. | ||||
| GC80932 | UNC10088 | - | >98.00% | |
UNC10088 is a molecular glue targeting NSD2. | ||||
| GC80933 | AMX-883 | 3102636-19-8 | >98.00% | |
AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. | ||||
| GC80934 | PROTAC BRD4 Degrader-49 | 3115940-40-1 | >98.00% | |
BRD4 degrader-8 is a BRD4 -targeting degrader. | ||||
| GC80935 | JQ1-JX5 | - | >98.00% | |
JQ1-JX5 is a DCAF16-based BRD4 PROTAC degrader. | ||||
| GC80936 | PROTAC BLIMP-1 degrader-1 | - | >98.00% | |
PROTAC BLIMP-1 degrader-1 is an orally active BLIMP-1 PROTAC degrader with an EC 50 of 13.1 nM. | ||||
| GC80937 | PROTAC KAT6 Degrader-1 | - | >98.00% | |
PROTAC KAT6 Degrader-1 is a CRBN-dependented KAT6 PROTAC degrader. | ||||
| GC80938 | DOT1L808 | - | >98.00% | |
DOT1L808 is a potent and highly selective DOT1L PROTAC degrader with a DC 50 value of 5 nM. | ||||
| GC80939 | MS115 TFA | 3109377-61-6 | >98.00% | |
MS115 TFA is a selective PRMT5/MEP50 PROTAC degrader, with DC 50 values of 17.4 nM and 11.3 nM for PRMT5 and MEP50, respectively. | ||||
| GC80946 | PROTAC JAK1/2 degrader-1 | - | >99.00% | |
PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively. | ||||
| GC80947 | JAK1/2 ligand 1 | 1026028-96-5 | >99.50% | |
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1. | ||||
| GC81024 | PROTAC RNF4 degrader-1 | - | >98.00% | |
PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system. | ||||
| GC81026 | PROTAC SKP2 Degrader-1 | 3120650-15-6 | >99.50% | |
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM. | ||||
| GC81027 | PROTAC HIF-1α degrader-2 | 3095636-64-6 | >98.00% | |
PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex. | ||||
| GC81031 | NEO-811 | 3084635-77-5 | >98.00% | |
NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. | ||||
| GC81312 | PARP1/c-Met-IN-3 | 3123529-62-1 | >98.00% | |
PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1. | ||||
| GC81357 | JZY3032 | - | >98.00% | |
JYZ3032 is an orally active super inhibitor of androgen receptor ( AR ) and p300/CBP. | ||||
| GC81400 | Adenosine-3',5'-bisphosphate ammonium solution (100 mM) | - | >99.00% | |
Adenosine-3',5'-bisphosphate ammonium is a XRN1 inhibitor ( IC 50 = 36 nM). | ||||
| GC81447 | ALDOA-IN-1 | - | >98.00% | |
ALDOA-IN-1 is an aldolase A (ALDOA) inhibitor. | ||||
| GC81481 | SKLB06489 | - | >98.00% | |
SKLB06489 is a selective and orally active inhibitor of type I PRMT enzymes, with IC 50 values of 64.55 nM ( PRMT1 ), 4.21 nM ( PRMT6 ), and 51.27 nM ( PRMT8 ). | ||||
| GC81499 | CT-179 | 1996636-69-1 | >99.50% | |
CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC 50 of 1250 nM. | ||||
| GC81512 | dCDK9-202 | - | >98.50% | |
dCDK9-202 is a CDK9 PROTAC degrader with a DC 50 of 3.5 nM. | ||||