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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Protein Ser/Thr Phosphatases

Protein Ser/Thr Phosphatases

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for  Protein Ser/Thr Phosphatases

  1. Cat.No. Product Name Information
  2. GC17344 Alexidine dihydrochloride An alkyl bis(biguanide) antiseptic Alexidine dihydrochloride Chemical Structure
  3. GC15974 bpV(HOpic) (potassium salt, technical grade)

    Bisperoxovanadium(HOpic)

     bpV(HOpic) (potassium salt, technical grade) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. bpV(HOpic) (potassium salt, technical grade) Chemical Structure
  4. GC17011 C2 Ceramide

    C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine

     A cell-permeable analog of naturally occurring ceramides C2 Ceramide Chemical Structure
  5. GC12082 Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor Cantharidic Acid (sodium salt) Chemical Structure
  6. GC12891 CCT007093 PPM1D inhibitor CCT007093 Chemical Structure
  7. GC15718 CID 2011756 An inhibitor of protein kinase D CID 2011756 Chemical Structure
  8. GC14024 DL-AP3 A metabotropic glutamate receptor antagonist DL-AP3 Chemical Structure
  9. GC14395 Fostriecin sodium salt A potent inhibitor of protein phosphatases 2A and 4 Fostriecin sodium salt Chemical Structure
  10. GC16117 INCA-6

    Triptycene-1,4-quinone

     A cell-permeant inhibitor of NFAT signaling INCA-6 Chemical Structure
  11. GC12189 LB-100 protein phosphatase 2A(PP2A)inhibitor LB-100 Chemical Structure
  12. GC17676 Nafamostat Broad spectrum serine protease inhibitor, kallikrein inhibitor Nafamostat Chemical Structure
  13. GC16290 Nafamostat hydrochloride Synthetic serine protease inhibitor Nafamostat hydrochloride Chemical Structure
  14. GC14875 NSC 663284

    Cdc25 Phosphatase Inhibitor II, DA30031, SPS8I1

     Cdc25 dual specificity phosphatases inhibitor NSC 663284 Chemical Structure
  15. GC11561 NSC 95397

    Cdc25 Inhibitor IV, PTP Inhibitor XXIX

     Cdc25 dual specificity phosphatases inhibitor NSC 95397 Chemical Structure
  16. GC16958 Okadaic acid A potent inhibitor of protein phosphatases Okadaic acid Chemical Structure
  17. GC16900 PRL-3 Inhibitor

    BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

     PRL-3 Inhibitor is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. PRL-3 Inhibitor shows a reduced invasion in cell-based assay. PRL-3 Inhibitor Chemical Structure
  18. GC15120 PTP Inhibitor I

    α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II

     PTP Inhibitor I a PTP1B inhibitor, with a Ki of 42 μM. PTP Inhibitor I Chemical Structure
  19. GC15804 PTP Inhibitor II

    α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II

     PTP Inhibitor II is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect. PTP Inhibitor II Chemical Structure
  20. GC15969 PTP Inhibitor IV

    Protein Tyrosine Phosphatase Inhibitor IV

     PTP inhibitor PTP Inhibitor IV Chemical Structure
  21. GC13442 Sanguinarine chloride Inhibitor of PP2C and MKP-1 Sanguinarine chloride Chemical Structure
  22. GC12498 Sephin1

    NSC 65390

     Sephin1 ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Sephin1 Chemical Structure
  23. GC11381 Tautomycetin protein phosphatase (PP)1 inhibitor Tautomycetin Chemical Structure
  24. GC11806 β-Glycerophosphate (sodium salt hydrate)

    Glycerol 2-Phosphate

     β-Glycerophosphate (sodium salt hydrate) is a phosphatase inhibitor. β-Glycerophosphate (sodium salt hydrate) Chemical Structure

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