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Home >> Signaling Pathways >> Chromatin/Epigenetics >> DNA Methyltransferase

DNA Methyltransferase

DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.

Products for  DNA Methyltransferase

  1. Cat.No. Product Name Information
  2. GC31365 γ-Oryzanol γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol Chemical Structure
  3. GC64210 (R)-GSK-3685032 (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition. (R)-GSK-3685032 Chemical Structure
  4. GC12775 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor 2',3',5'-triacetyl-5-Azacytidine Chemical Structure
  5. GC73073 5-Aza-4'-thio-2'-deoxycytidine

    5-Aza-T-dCyd; NTX-301

     5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA metltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine Chemical Structure
  6. GC10946 5-Azacytidine

    Antibiotic U 18496, 5AzaC, Ladakamycin, Mylosar, NSC 102816, NSC 103627, U 18496, WR 183027

     5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively. 5-Azacytidine Chemical Structure
  7. GC61662 5-Fluoro-2'-deoxycytidine 5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP. 5-Fluoro-2'-deoxycytidine Chemical Structure
  8. GC42562 5-Methyl-2'-deoxycytidine

    5Methyldeoxycytidine

     5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. 5-Methyl-2'-deoxycytidine Chemical Structure
  9. GC35180 6-Methyl-5-azacytidine 6-Methyl-5-azacytidine is a potent DNMT inhibitor. 6-Methyl-5-azacytidine Chemical Structure
  10. GC34498 Bobcat339 hydrochloride Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription. Bobcat339 hydrochloride Chemical Structure
  11. GC12367 CM-272 CM-272 is a first-in-class reversible dual inhibitor against G9a and DNMTs with IC50 values of 8 nM and 382 nM, respectively [1]. CM-272 Chemical Structure
  12. GC33320 CM-579 CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. CM-579 Chemical Structure
  13. GC35714 CM-579 trihydrochloride CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. CM-579 trihydrochloride Chemical Structure
  14. GC33148 DC-05 DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively. DC-05 Chemical Structure
  15. GC32872 DC_517 DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 Chemical Structure
  16. GC15255 Decitabine(NSC127716, 5AZA-CdR)

    DAC, 5aza2’Deoxycytidine, NSC 127716

     Decitabine(DAC) is a deoxycytidine analogue antimetabolite with oral bioactivity and functions as an inhibitor of DNA methyltransferase. Decitabine(NSC127716, 5AZA-CdR) Chemical Structure
  17. GC65546 DNMT3A-IN-1 DNMT3A-IN-1 is a potent and selective DNMT3A inhibitor. DNMT3A-IN-1 Chemical Structure
  18. GC69030 DY-46-2

    DY-46-2 is a new and highly efficient, selective inhibitor of DNA methyltransferase 3A (DNMT3A) that has an IC50 value of 1.3 μM.

     DY-46-2 Chemical Structure
  19. GC36153 Glucose-conjugated MGMT inhibitor Glucose-conjugated MGMT inhibitor is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. Glucose-conjugated MGMT inhibitor Chemical Structure
  20. GC63483 GSK-3685032 GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition. GSK-3685032 Chemical Structure
  21. GC69194 GSK3735967

    GSK3735967 is a selective, reversible, non-nucleoside DNMT1 inhibitor. It contains a planar dicyanopyridine core that can specifically embed into the semi-methylated CpG dinucleotide bound by DNMT1. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3.

     GSK3735967 Chemical Structure
  22. GC36196 Guadecitabine sodium

    SGI-110 sodium; S-110 sodium

     Guadecitabine is a novel hypomethylating dinucleotide of decitabine and deoxyguanosine that is resistant to degradation by cytidine deaminase. Guadecitabine sodium Chemical Structure
  23. GC11302 Hinokitiol

    NSC 18804, β-Thujaplicin, 4-isopropyl Tropolone

     A tropolone with diverse biological activities Hinokitiol Chemical Structure
  24. GC11778 Lomeguatrib

    PaTrin 2

    Inactivator of O6-methylguanine-DNA methyltransferase

     Lomeguatrib Chemical Structure
  25. GC73972 METTL1-WDR4-IN-2 METTL1-WDR4-IN-2(compound 6) is a selective metltransferase Like 1 (METTL1)-WDR4 inhibitor with an IC50 of 41 μM. METTL1-WDR4-IN-2 Chemical Structure
  26. GC73949 METTL16-IN-1 METTL16-IN-1 (Compound 45) is a potent METTL16 inhibitor with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. METTL16-IN-1 Chemical Structure
  27. GC14562 Nanaomycin A

    Nanafrocin, Nanafrocine, Nanafrocinum, Rosanomycin A

     A bacterial metabolite Nanaomycin A Chemical Structure
  28. GC10243 Nanaomycin C

    Amide of nanaomycin A

     Nanaomycin C Chemical Structure
  29. GC64733 Procainamide Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide Chemical Structure
  30. GC60310 Psammaplin A Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A Chemical Structure
  31. GC13398 RG 108

    N-Phthalyl-L-tryptophan,RG108

     DNA methyltransferase inhibitor RG 108 Chemical Structure
  32. GC14364 SGI-1027

    DNA Methyltransferase Inhibitor II

     DNMT inhibitor SGI-1027 Chemical Structure
  33. GC17428 SGI-110

    SGI-110

     SGI-110 Chemical Structure
  34. GC65242 TFMB-(S)-2-HG TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML). TFMB-(S)-2-HG Chemical Structure
  35. GC14366 Thioguanine

    NSC 752, NSC 76504, 6TG

     A thiopurine analog Thioguanine Chemical Structure
  36. GC12153 Zebularine A DNA methyltransferase inhibitor Zebularine Chemical Structure

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