Ubiquitination/ Proteasome

A degrader of NSD2

A prolyl endopeptidase inhibitor

N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.

8RK64 is a covalent inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50 = 0.32 µM) and a click chemistry reagent.

FDW028 is an inhibitor of fucosyltransferase 8 (FUC8).

SB-02024 is an inhibitor of vacuolar protein sorting 34 (VPS34; IC50 = 5 nM).

WYneC is a chemoselective probe for the detection of sulfenylated proteins in live cells.

WYneN is a chemoselective probe for the detection of sulfenylated proteins in live cells.

WyneO is a probe for the detection of sulfenylated proteins.

PTX80 is an antagonist of p62 (IC50 = 31.18 nM for the human receptor).

CellFluor GST is a cell-permeable quenched fluorescent probe for the detection of pan-glutathione S-transferase activity in adherent or suspension cells, cell or tissue lysates, or purified enzyme preparations.

Lipoteichoic acid is a teichoic acid predominantly located in the cell walls of Gram-positive bacteria, widely involved in stimulating immune responses and cellular signaling pathways.

Cathepsin B from bovine spleen (Cathepsin B) is a member of the cysteine protease papain-like family. Cathepsin B is synthesized as a preproenzyme consisting of 335 amino acids, with a calculated molecular weight of approximately 36.7kDa. Cathepsin B is localized in the endosomal/lysosomal compartment, where Cathepsin B functions as both an endopeptidase and an exopeptidase. Cathepsin B primarily participates in the routine turnover of intracellular and extracellular proteins, thereby maintaining the homeostatic metabolic activity within the cell.

Wogonin is a potent and competitive inhibitor of CYP1A2 with a K i value of 0.24μM.

Baicalin is a flavonoid glycoside and an allosteric carnitine palmitoyltransferase 1 (CPT1) activator.

Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs) and is an effective drug widely used in the clinic to treat malaria.

Arctigenin,a natural lignan compound,has demonstrated anticancer activities in cancer. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities.

Isoliquiritigenin is a flavonoid compound derived from licorice. Isoliquiritigenin can activate the Nrf2 pathway to reduce oxidative stress and inflammation, while also inhibiting cancer progression by inducing apoptosis.