Arctigenin |
Catalog No.GN10063
One-Click Copy Product Info
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Arctigenin,a natural lignan compound,has demonstrated anticancer activities in cancer. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7770-78-7
Sample solution is provided at 25 µL, 10mM.
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Arctigenin,a natural lignan compound,has demonstrated anticancer activities in cancer. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities [3,4].
Arctigenin (40 µM;48h) inhibited the growth of U87MG and T98G cells, induced G0/G1 cell-cycle arrest and triggered cell apoptosis in glioma cells[1]. Arctigenin (10,20,40,80 and 100μmol/L;48h) possesses anti-tumor activity in bladder cancer T24 cells. At the molecular level, arctigenin was able to reduce cyclin D1 and phospho-ERK1/2 expression, but induce phospho-p38 levels[4]. Arctigenin (0,1.56,12.5,100 μM; 24h) induce apoptosis in HCC cells via mitochondria and Fas/FasL-dependent apoptotic pathways[5].
Arctigenin (25 mg/kg;ip; twice daily ) for 23 day increased insulin-stimulated AKT phosphorylation in gastrocnemius muscle and liver, but not in perirenal fat[2]. Arctigenin (50mg/kg/day;ip) for 4 day confers protection against LPS-induced lung inflammatory and oxidative damage [6].
References:
[1]. Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A, Li W. Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells. Oncol Lett. 2017 Feb;13(2):1007-1013
[2]. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD, Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 2012 May;55(5):1469-81.
[3]. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205.
[4]. Yang S, Ma J, Xiao J, Lv X, Li X, Yang H, Liu Y, Feng S, Zhang Y. Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis. Anat Rec (Hoboken). 2012 Aug;295(8):1260-6.
[5]. Lu Z, Cao S, Zhou H, Hua L, Zhang S, Cao J. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PLoS One. 2015 May 1;10(5):e0125727.
[6]. Zhang WZ, Jiang ZK, He BX, Liu XB. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling. Inflammation. 2015 Aug;38(4):1406-14.
| Cell experiment [1]: | |
Cell lines | U87MG and T98G human glioma cell lines |
Preparation Method | The U87MG and T98G human glioma cell lines were treated with Actigenin ( 1-40μM ) for 48 h. |
Reaction Conditions | Actigenin ( 1-40μM ) ;48 h |
Applications | Arctigenin dose-dependently inhibited the growth of U87MG and T98G cells. |
| Animal experiment [2]: | |
Animal models | Female ob/ob mice modle |
Preparation Method | Female ob/ob mice were given Arctigenin (25 mg/kg;ip; twice daily ) for 22 day. |
Dosage form | Arctigenin (200 mg/kg q2d);23 day;ip. |
Applications | Arctigenin (25 mg/kg;ip;twice daily )increased insulin-stimulated AKT phosphorylation in gastrocnemius muscle and liver,but not in perirenal fat. |
References: | |
| Cas No. | 7770-78-7 | SDF | |
| Chemical Name | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | ||
| Canonical SMILES | COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC | ||
| Formula | C21H24O6 | M.Wt | 372.41 |
| Solubility | ≥ 17.2mg/mL in DMSO | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6852 mL | 13.4261 mL | 26.8521 mL |
| 5 mM | 537 μL | 2.6852 mL | 5.3704 mL |
| 10 mM | 268.5 μL | 1.3426 mL | 2.6852 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)